Position description:

Calico is seeking an experienced NGS scientist with a particular passion for single cell and spatial transcriptomics technology. As a member of our Genomics group your results will directly contribute to Calico’s long-term mission of positively impacting human healthspan and lifespan. 

In this role you will act as a technical domain expert for single cell and spatial transcriptomics technology at Calico, ensuring that we have access to technology that is state-of-the-art or beyond. 

Laboratory responsibilities:

• Improve Calico’s single cell and spatial transcriptomics methods, including experimental design, sample preparation, library construction, data generation


• Innovate and create novel approaches for droplet and plate-based assays


• Provide single cell technical guidance to your colleagues


• Teach/mentor junior colleagues

Analysis responsibilities:

• Employ existing data NGS bioinformatic analysis tools, develop new bioinformatic analysis tools as needed to analyze your data


• Provide NGS bioinformatic analysis expertise to colleagues


• Present results at internal lab meetings and company-wide meetings


• Publish results and present at external scientific conferences

Position requirements:

• PhD plus postdoc in molecular biology, genetics, genome sciences, bioengineering, bioinformatics, or related field


• At least 4 years prior hands-on laboratory NGS experience with demonstrated proficiency with extant NGS library methods (RNA-seq, ATAC-seq, IsoSeq or other)


• At least 3 years NGS computational coding experience (Python, R, extant NGS bioinformatics analysis tools)


• Prior management/mentoring experience

Nice to have:

• Experience with computational and statistical approaches for high-dimensional data analysis


• Experience with laboratory robotics, large-scale experiments and process development


• Familiarity with droplet-based and plate-based single cell assays and platforms (sci-Seq, InDrop, Drop-Seq, SMART-seq, 10x Genomics, Rhapsody, Fluidigm, Dolomite Bio, etc.)


• Experience with cell culture techniques and tissue processing